The Marmoset Brain Architecture
  • ABOUT
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    • Mouse Wildtype Connectivity
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      • Single Cell RNA-seq
      • Cell Type: Nuclear Label WT
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3D Cursor
3D Cursor Search: Move cursor to desired injection location

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Data Navigation

– 3D Cursor Search: Click on a point to find the coordinates and region to view image data and injected datasets.

– Tree Search: Use brain region hierarchy to search for specific regions and areas to access injected dataset information

– 3D Rendering: Hover over injection sites to view coordinates and datasets, click to access viewer

 

About the Data

Datasets include marmoset information, tracer injection location, and image details to visualize projections

Specified regions and areas throughout the brain

Projection patterns and defined neuronal populations

* Images acquired by high resolution Nanozoomer 2.0HT digital scanning

 

About the Marmoset Connectivity Atlas

Grid-based tracer injection strategy for systematic mesoscale connectivity mapping

Combining the resulting 3D volumes, containing informative cytoarchitectonic markers, with in-vivo and ex-vivo MRI, and using an integrated computational pipeline

Tracer injections systematically placed on a grid of locations spanning the brain and computational analysis of the resulting whole brain data sets

Publications/Preprints

[Link] Meng Kuan Lin, Yeonsook Shin Takahashi, Bing-Xing Huo, Mitsutoshi Hanada, Jaimi Nagashima, Junichi Hata, Alexander S. Tolpygo, Keerthi Ram, Brian C. Lee, Michael I. Miller, Marcello G. P. Rosa, Erika Sasaki, Atsushi Iriki, Hideyuki Okano, Partha P. Mitra. (2019). A High-throughput Neurohistological Pipeline for Brain-Wide Mesoscale Connectivity Mapping of the Common Marmoset. eLife; doi: https://elifesciences.org/articles/40042

[Link] Hideyuki Okano, Partha Mitra (2015). Neuroscience Research: Brain-mapping projects using the common marmoset. 93,3-7, doi: https://doi.org/10.1016/j.neures.2014.08.014

[Link] Bing-Xing Huo, Natalie Zeater, Meng Kuan Lin, Yeonsook Shin Takahashi, MitsutoshiHanada, Jaimi Nagashima, Brian C. Lee, Junichi Hata, Ulrike Grunert, Michael I. Miller, Marcello G.P. Rosa, Hideyuki Okano, Paul R. Martin, Partha P. Mitra. (2019). Relation of koniocellular layers of dorsal lateral geniculate to inferior pulvinar nuclei in common marmosets. Eur J Neurosci. ; doi: https://doi.org/10.1111/ejn.14529

[Link] Marcello G.P. Rosa, Piotr Majka, Shi Bai, Jonathan M. Chan, Bing-Xing Huo, NataliaJermakow, Meng Kuan Lin, Yeonsook S. Takahashi, Ianina H. Wolkowicz, Katrina H.Worthy, Ramesh Rajan, David H. Reser, Daniel K. Wojcik, Hideyuki Okano, Partha P.Mitra. (2019). Unidirectional monosynaptic connections from auditory areas to the primary visual cortex in the marmoset monkey. Brain Struct Function; doi: https://doi.org/10.1007/s00429-018-1764-4

[Link] Brian C. Lee, Meng Kuan Lin, Yan Fu, Junichi Hata, Michael I. Miller, Partha P. Mitra. Joint Atlas-Mapping of Multiple Histological Series combined with Multimodal MRI of Whole Marmoset Brains. arXiv:1805.04975.

[PDF] Meng Kuan Lin, Yeonsook Shin Takahashi, Khurshida Hossain, Bing-Xing Huo, Kevin Weber, Alexander S. Tolpygo, Daniel Ferrante, Junichi Hata, Jonathan Chan, Akiya Watakabe, Noriyuki Kishi, Atsushi Iriki, Marcello G.P.Rosa, Erika Sasaki, Hideyuki Okano, Partha P. Mitra. Marmoset Brain Architecture Project: A high-throughput Neurohistological pipeline for Brain-wide Mesoscale connectivity mapping of Marmoset. Poster session presented at: The 39th Annual Meeting of the Japan Neurosceience Society; 2016 July 20-22; Yokohama, JP.

[PDF] Meng Kuan Lin, Yeonsook Shin Takahashi, Kevin Weber, Bing-Xing Huo, Alexander S. Tolpygo, Daniel Ferrante, Shi Bai, Marcello G.P. Rosa, Hideyuki Okano, Partha P. Mitra. Computational infrastructure to enable whole-brain mesoscale circuit mapping for marmoset. Poster session presented at: Society for Neuroscience; 2016 Nov 12-16; San Diego, USA.

Partha P. Mitra, Yeonsook Shin Takahashi, Kevin Weber, Meng Kuan Lin, Khurshida Hossain, Bing-Xing Huo, Alexander S. Tolpygo, Daniel Ferrante, Junichi Hata, Jonathan Chan, Hiroaki Mizukami, Akiya Watakabe, Tetsuo Yamamori, Noriyuki Kishi, Atsushi Iriki, Marcello G.P.Rosa, Erika Sasaki, Hideyuki Okano. A high-throughput neurohistological pipeline for whole-brain mesoscale circuit mapping for marmoset. Oral symposium presented at: Society for Neuroscience; 2016 Nov 12-16; San Diego, USA.

[PDF] Meng Kuan Lin, Yeonsook Shin Takahashi, Kevin Weber, Bing-Xing Huo, Mitsutoshi Hanada, Alexander S. Tolpygo, Daniel Ferrante, Marcello G.P. Rosa, Hideyuki Okano, Partha P. Mitra. Assembly of a High Efficiency Computational Pipeline for Marmoset Brain Mapping. Poster session presented at: Asia-Oceania Reginal Meeting for Marmoset Research; 2017 March 16-17; Seoul, ROK

[PDF] Marcello G.P. Rosa, Piotr Majka, KH Worthy, Yeonsook Shin Takahashi, Meng Kuan Lin, Ianina Ruth Hutler Wolkowicz, Alexander S. Tolpygo, Shi Bai, Bing-Xing Huo, Jonathan M. Chan, Erika Sasaki, David H. Reser, Partha P. Mitra. Monosynaptic connections between auditory and visual areas in the marmoset monkey. Poster session presented at: Society for Neuroscience; 2017 Nov 11-15; Washington DC, USA

Bing-Xing Huo, Meng Kuan Lin, Yeonsook Shin Takahashi, Mitsutoshi Hanada, Jaimi Nagashima, Alexander S. Tolpygo, Brian Lee, Michael Miller, Marcello G.P. Rosa, Hideyuki Okano, Partha P. Mitra. Toward the mesoscopic whole-brain neural connectivity in marmosets. Oral symposium presented at: Winter Conference on Brain Research; 2018 Jan 14-19; Whistler, CA

[PDF] Meng Kuan Lin, Yeonsook Shin Takahashi, Mitsutoshi Hanada, Jaimi Nagashima, Bing-Xing Huo, Alexander S. Tolpygo, Brian C. Lee, Michael I. Miller, Marcello G.P. Rosa, Hideyuki Okano, Partha P. Mitra. A connectivity mapping of marmoset brain by an established computational image processing pipeline. Poster session presented at: Poster session presented at: Japanese Society for Marmoset Research; 2018 July 27-29; Kobe, JP

Monash Group
Flat Map Navigator

Monash Group
Connectivity Matrix

About the Project

The Marmoset Brain Connectivity Project is a collaborative effort aimed at generating a mesoscale connectivity map for the Marmoset, using anterograde and retrograde tracer injections. The data presented on the portal were generated at Monash University (Australia) and RIKEN BSI (Japan).

The project was initiated through a collaborative interaction with the Rosa laboratory at Monash University (Australia) in 2010, with an effort to digitize and place online a set of already collected retrograde tracer-labelled cells. Subsequently the project was expanded by including data generated in a collaboration between the Mitra and Okano laboratories as part of the Japanese Brain/MINDS initiative.

A copy of the high-throughput neurohistological and computational pipeline of the Mouse Brain Architecture Project was established in 2014 at the RIKEN Brain Science Institute by Dr Mitra’s group, which is also responsible for the analysis and portal display here of the corresponding data set consisting of a set of anterograde and retrograde tracer injections placed on a systematic brain-wide grid.

– Brain/MINDS: A Japanese National Brain Project for Marmoset Neuroscience.

– Brain/MINDS: Brain-Mapping Project in Japan.

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